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Holly Neibergs |
ANIMAL GENOMICS. Recent advances in animal genetics have accelerated with the use of genomics. This laboratory focuses on the use of mammalian comparative and functional genomics in the search for genes of economic significance. This includes identification of genes involved in disease resistance as well as production traits with the use of linkage, epidemiological and functional approaches. By utilizing different approaches to unravel the genetic basis of complex traits, these studies offer new tools for genetic selection and improvement of animals and understanding and exploring the physiology underlying these traits.
Specific Research Areas:
- Comparative organization of vertebrate genomes.
- Genetics of disease susceptibility.
- Complex traits of economic significance.
Selected Publications:
- Neibergs, H.L., D.W. Hein, J.S. Spratt. Genetic profiling of colon cancer. 2002. Journal of Surgical Oncology 80:204-313.
- Neibergs, H.L. Molecular genetics and cancer: The role of BRCA1 and BRCA2. 2002. Women's Oncology Review 2:19-29.
- Brennan, M.D., H.L. Neibergs, K. Phillips, S. Moseley. 2000. Polymorphic markers for the arylsulfatase A gene reveal a greatly expanded meiotic map for the human 22q telomeric region. Genomics 63:430-432.
- Bosworth, B.T., E. Dean-Nystrom, T.A. Casey, H.L. Neibergs. 1998. Differentiation of F18ab+ from F18ac+ Escherichia coli using single-strand conformational polymorphism analysis of the major fimbrial subunit gene (fedA). Clinical and Diagnostic Laboratory Immunology 5(3):299-302.
- Hofmeister, A., H.L. Neibergs, R.M. Pokorny, S. Galandiuk. 1997. The natural resistance associated macrophage protein (NRAMP) gene is associated with Crohn's disease: An epidemiologic approach. Surgery 122:173-179.
- Pokorny, R.M., A. Hofmeister, S. Galandiuk, A.B. Dietz, N.D. Cohen, H.L. Neibergs. 1997. Crohn's disease and ulcerative colitis are associated with the DNA repair gene MLH1. Annals of Surgery 225, 6:718-725.
- Pokorny, R.M., S.G. Galandiuk, A.B.Dietz, H.L. Neibergs. 1997. Improved resolution of asymmetric PCR-SSCP products. BioTechniques 22:606-608.
- Cohen N.D., L.J. Martin, R.B. Simpson, D.E. Wallis, H.L. Neibergs. 1996. Comparison of PCR and microbiological culture for detection of salmonellae in equine feces and environmental samples. American Journal Veterinary Research 57:780-786.
- Barendse, W., S.M. Armitage, L. Kossarek, A. Shalom, B.W. Kirkpatrick, A.M. Ryan, D. Clayton, L. Li, H. Neibergs, N. Zhang, W.M. Grosse, J. Weiss, P. Creighton, F. McCarthy, M. Ron, A.J.Teale, R. Fries, R.A. McGraw, S.S. Moore, M. Georges, M. Soller, J.E. Womack, D.J.S. Hetzel. 1994. A genetic linkage map of the bovine genome. Nature Genetics 6:227-235.
- Neibergs, H.L., A.M. Ryan, R.L. Spooner, J.E. Womack, J.L. Williams. 1994. Polymorphism analysis of the prion gene in BSE affected and unaffected cattle. Animal Genetics 25:313-317.