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Zhihua Jiang Associate Professor and Associate Animal Scientist Postdoctoral Research Fellow, Roslin Institute, Scotland Postdoctoral Research Fellow, CNRS, France Phone: (509) 335-8761 Email: jiangz@wsu.edu

COMPARATIVE GENOME BIOLOGY  Although mammalian genomes have each been shuffled by chromosome rearrangements since their divergence from a common ancestor, most ancestral orthologous genes are retained within each genome.  Due to the advantages of their sequence similarities, large numbers, genome wide distributions and precise localizations, the orthologous genes are universal and unique landmarks to correlate different genomes.   Our research has been focused on how orthologous genes have evolved in terms of their sequences, mapping, expression and function in different mammalian species. Comparative genome biology promises to significantly benefit the livestock industry by providing knowledge and technologies that can help optimize production, quality, nutritional value and resistance to diseases.  As a return, our program enables development of animal models to unravel the genetic basis of complex traits such as many of those affecting human health.

Specific Research Areas:

• Deep annotation of animal genomes.
• Genomically standardized farming and pharming.
• Mitochondriomics.

Selected Publications:

1. Chen J, Guridi M, Fernyhough ME, Jiang Z, Guan LL, Hausman GJ, Dodson MV. 2009. Clonal mature adipocyte production of proliferative-competent daughter cells requires lipid export prior to cell division. International Journal of Stem Cells (in press).
2. Xu XL, Xu XW, Pan PW, Li K, Jiang Z, Yu M, Rothschild MF, Liu B.  2009.  Porcine skeletal muscle differentially expressed gene CMYA1: isolation, characterization, mapping, expression and association analysis with carcass traits.  Animal Genetics (in press).
3. Jiang Z, Rokhsar DS, Harland RM. 2009.  Old can be new again: HAPPY whole genome sequencing, mapping and assembly.  International Journal of Biological Sciences 5:298-303.
4. Hausman GJ, Dodson MV, Ajuwon K, Azain M, Barnes KM, Guan LL, Jiang Z, Poulos SP, Sainz RD, Smith S, Spurlock M, Novakofski J, Fernyhough ME, Mersmann H. 2009.  Board Sponsored Invited Review: Domestic animal carcass composition: The biology and regulation of preadipocytes and adipocytes.  Journal of Animal Science 87:1218-1246.
5. Wang XX, Xue CY, Wang XN, Liu HL, Xu YX, Zhao RQ, Jiang Z, Dodson MV, Chen J. 2009. Differential display of expressed genes reveals a novel function of SFRS18 in regulation of intramuscular fat deposition.  International Journal of Biological Sciences 5: 28 - 33.
6. Jiang Z, Wu X-L, Zhang M, Michal JJ, Wright Jr. RW.  2008.  The complementary neighborhood patterns and methylation-to-mutation likelihood structures of 15,110 single nucleotide polymorphisms in the bovine genome.  Genetics 180:639-647.
7. Wibowo TA, Gaskins CT, Newberry RC, Thorgaard GH, Michal JJ, Jiang Z. 2008.  Genome assembly anchored QTL map of bovine chromosome 14.  International Journal of Biological Sciences 4:406 – 414.
8. Wang XX, Chen J, Liu HL, Xu YX, Wang XN, Xue CY, Yu DB, Jiang Z.  2008. The pig p160 co-activator family: full length cDNA cloning, expression and effects on intramuscular fat content in Longissimus Dorsi muscle.  Domestic Animal Endocrinology 35: 208 – 216.
9. Jiang Z, Michal JJ, Tobey DJ, Daniels TF, Rule DC, MacNeil MD.  2008. Significant associations of stearoyl-CoA desaturase(SCD1) gene with fat deposition and composition in skeletal muscle.  International Journal of Biological Sciences 4:345 – 351.
10. Jiang Z, Michal JJ, Tobey DJ, Wang Z, MacNeil MD, Magnuson NS. 2008. Comparative understanding of UTS2 and UTS2R genes for their involvement in type 2 diabetes mellitus.  International Journal of Biological Sciences 4: 96-102.
11. Chen J, Yang XJ, Xia D, Chen J, Wegner J, Jiang Z, Zhao RQ. 2008. SREBF1 expression and genetic polymorphism significantly affect intramuscular fat deposition in the longissimusmuscle of Erhualian and Sutai pigs.  Journal of Animal Science 86:57-63.