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Zhihua Jiang |
COMPARATIVE GENOME BIOLOGY Although mammalian genomes have each been shuffled by chromosome rearrangements since their divergence from a common ancestor, most ancestral orthologous genes are retained within each genome. Due to the advantages of their sequence similarities, large numbers, genome wide distributions and precise localizations, the orthologous genes are universal and unique landmarks to correlate different genomes. Our research has been focused on how orthologous genes have evolved in terms of their sequences, mapping, expression and function in different mammalian species. Comparative genome biology promises to significantly benefit the livestock industry by providing knowledge and technologies that can help optimize production, quality, nutritional value and resistance to diseases. As a return, our program enables development of animal models to unravel the genetic basis of complex traits such as many of those affecting human health.
Specific Research Areas:
- Deep sequencing and annotation of animal genomes.
- Genomically optimized livestock farming (GOLF).
- Animal model genomics.
Most Frequently Cited Publications:
1. Priat C, Hitte C, Vignaux F, Renier C, Jiang Z, Jouquand S, Chéron A, André C, Galibert F. 1998. A whole-genome radiation hybrid map of the dog genome. Genomics 54:361-378. (Times cited: 117)
2. Jiang Z, Priat C, Galibert F. 1998. Traced orthologous amplified-sequence tags (TOASTs) and mammalian comparative maps. Mammalian Genome 9:577-587. (Times cited: 74)
3. Rothschild MF, Hu Z-L, Jiang Z. 2007. Advances in QTL mapping in pigs. International Journal of Biological Sciences 3:192-197. (Times cited: 52)
4. Schenkel FS, Miller SP, Jiang Z, Mandell IB, Ye X, Li H, Wilton JW. 2006. Association of a single nucleotide polymorphism in the calpastatin (CAST) gene with carcass and meat quality traits of beef cattle. Journal of Animal Science 84:291-299. (Times cited: 51)
5. Jiang Z, Gibson JP. 1999. Genetic polymorphisms in the leptin gene and their association with fatness in four pig breeds. Mammalian Genome 10:191-193. (Times cited: 46)
6. King AM, Jiang Z, Gibson JP, Haley CS, Archibald AL. 2003. Mapping quantitative trait loci affecting female reproductive traits on porcine chromosome 8. Biology of Reproduction 68:2172-2179. (Times cited: 43)
7. Michal JJ, Zhang ZW, Gaskins CT, Jiang Z. 2006. The bovine fatty acid binding protein 4 gene is significantly associated with marbling and subcutaneous fat depth in Wagyu x Limousin F2 crosses. Animal Genetics 37:400-402. (Times cited: 41)
8. Lahbib-Mansais Y, Leroux S, Milan D, Yerle M, Robic A, Jiang Z, Andre C, Gellin J. 2000. Comparative mapping between humans and pigs: localization of 58 anchorage markers (TOASTs) using porcine somatic cell and radiated hybrid panels. Mammalian Genome 11:1098-1106. (Times cited: 36)
9. Hausman GJ, Dodson MV, Ajuwon K, Azain M, Barnes KM, Guan LL, Jiang Z, Poulos SP, Sainz RD, Smith S, Spurlock M, Novakofski J, Fernyhough ME, Mersmann H. 2009. Board Sponsored Invited Review: Domestic animal carcass composition: The biology and regulation of preadipocytes and adipocytes. Journal of Animal Science 87:1218-1246. (Times cited: 33)
10. Jiang Z, Kunej T, Michal JJ, Gaskins CT, Reeves JJ, Busboom JR, Dovc P, Wright Jr. RW. 2005. Significant associations of the mitochondrial transcription factor A (TFAM) promoter polymorphisms with marbling and subcutaneous fat depth in Wagyu x Limousin F2 crosses. Biochemical and Biophysical Research Communications 334:516-523. (Times cited: 26)